Advances in the Synthesis and Pharmacological Applications of Heterocyclic Scaffolds: Benzoxepine and Benzothiepine Derivatives

Sanjay K. Gautam; Pushyamitra Mishra; Balendu K. Gupta; Anoop K. Awasthi; Vishnu K. Tandon

doi:10.59828/ijsrmst.v2i7.127

Authors

Sanjay K. Gautam Department of Chemistry, University of Lucknow, Lucknow. U.P. India, 226007 Author
Pushyamitra Mishra Department of Chemistry, Shri Lal Bahadur Shastri Degree College Gonda, Uttar Pradesh, India Author
Balendu K. Gupta Department of Chemistry, University of Lucknow, Lucknow. U.P. India, 226007 Author
Anoop K. Awasthi Lokmata Devi Ahilya Bai Holkar Rajkiya Engineering College, Mainpuri U.P. India. Author
Vishnu K. Tandon Department of Chemistry, University of Lucknow, Lucknow. U.P. India, 226007 Author

DOI:

https://doi.org/10.59828/ijsrmst.v2i7.127

Abstract

Paul Cagniant first reported the synthesis of benzoxepine which was named as homochroman 1.¹ Since then a large number of substituted benzoxepine derivatives were prepared by various synthetic routes, the significant being (i) By rearrangement of anisylidine flavone epoxides;² (ii) From dihydrobenzofuran-3-one;³ (iii) By PARHAM Cyclialkylation;^4,5 (iv) From aryl oxazolines;⁶ (v) By ring closure of Isoprenyl terminal epoxides;⁷

Homochroman (1-Benzoxepine and 1-Benzothiepine)

(vi) By photocycloaddition of Benzo[b]furan derivatives to alkenes;⁸ and several other synthetic routes not being employed in common practice. The thia analog is known as benzothiepine 1a.

A review on Benzoxepines has described the synthetic routes reported in literature till 1990.^9,10 The present review describes the synthetic routes, reactions, the naturally occurring 1-Benzoxepines, its derivatives and their pharmacological significance.

Keywords: Benzoxepine and Benzothiepine, synthetic routes, reactions, pharmacological significance.