Anti-Carcinogenic Activity of Ethanolic Seed Extract of Zizipus Jujuba in DMBA Induced Charles Foster Rat

. Akanchha; Ayesha  Kaushar; Reshma  Sinha

doi:10.59828/ijsrmst.v5i6.441

Authors

. Akanchha Research Scholar, Patliputra University, Patna, Bihar, India Author
Ayesha Kaushar Research Scholar, Patliputra University, Patna, Bihar, India Author
Reshma Sinha Assistant Professor, Department of Zoology, J.D. Women’s College, (Affiliated with Patliputra University), Patna, Bihar, India Author

DOI:

https://doi.org/10.59828/ijsrmst.v5i6.441

Keywords:

DMBA, Breast tumor, Mammary Carcinoma, Ziziphus jujuba, Charles Foster Rats, Tumor Volume, Anti-carcinogenic Activity

Abstract

The anti-carcinogenic potential of ethanolic extract derived from Ziziphus jujuba seeds against breast cancer induced by 7,12-Dimethylbenz[a]anthracene (DMBA) in Charles Foster rats. Mammary tumoriogenesis was initiated via oral gavage of DMBA, solubilised in olive oil, at a dose of 15 mg per kilogram of body weight through oral administration. Once tumors started to appear, the rats were given the ethanolic seed extract of Ziziphus jujuba at a dose of 300 mg/kg body weight every day for five weeks. The development of tumors and the response to treatment were regularly checked by measuring the size of the tumors using Vernier calipers.

The results showed that the group of rats treated with the extract demonstrated a significant reducing in tumor within the extract-treated cohort relative to the untreated control animals. This reduction suggests that the extract has a protective effect against DMBA-induced mammary tumor development against cancer caused by chemical exposure. These outcomes suggest the ethanolic extract of Ziziphus jujuba seeds possesses substantial anti-tumor properties, highlighting its potential viability as a therapeutic agent of natural origin for managing mammary carcinoma.