Effect of antioxidant activity of Tinospora cordifolia on the hemato-biochemical profile in Wistar rats exposed to passive smoking

Abstract

Passive and active exposure to cigarette smoke is a major leading cause of preventable diseases in humans and animals. Therefore, the main aim of the present study was to investigate the dose-dependent effect of Tinospora cordifolia (TC) fresh aqueous leaf extract on hematological and biochemical changes in rats exposed sub-chronically to filtered and non-filtered cigarette smoke. Healthy and adult albino rats of both sexes were exposed to filtered (FC) and non-filtered cigarette (NFC) cigarette smoke for 1 hr/day. The effect of two different doses of TC was studied in these rats. The study was conducted in 2 phases to observe the effect of FC and NFC and the effect of TC after 30 and 60 days. The results clearly confirmed that sub-chronic passive exposure to cigarette smoke had damaging effects on hemato-biochemical profile of rats and that these effects were modulated in groups supplemented with TC leaf extract. The parameters studied were DLC, ESR, AST, ALT, urea, creatinine and blood glucose. It may be concluded that TC extract supplementation attenuated the harmful effects on hematological and biochemical parameters of rats sub-chronically exposed to passive smoke. Thus, the antioxidant property of TC helps to boost the immune system of the body, which is regularly exposed to passive smoking.