Ameliorative Efficacy of Leaf Extract of Moringa oleifera on Protein Profile Aluminium- Induced in Albino Rats

Abstract

Aluminium is a broadly distributed element with a well-known toxicity. The present work was designed to study the protective effect of the Moringa oleifera leaf extract on aluminium induced changes in protein profile in male albino rats. A total sixty healthy male albino rats equal weight and size were grouped into three groups of 20 rats each. Group 1: Control normal food and distilled water. Group 2: aluminium 200 mg /kg b. w. Group 3: 300 mg / kg b. w of leaf extract of M. oleifera along with same dose of Al for total 60 days. Blood samples were collected at 45 and 60 days for analysis of protein profile Albumin, A/ G ratio and Total protein. The outcome of current study revealed a significant decrease in the activities of Albumin , A/G ratio and TP after Al subjection compared to control group. There was a significant increase in Group 3 in all days. The finding demonstrated ameliorative potentials of aqueous leaf extract of Moringa oleifera against damages induced by Al in a dose and time selected manner.